What Is VDR?

VDR is a gene that encodes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone development. A variant of the gene (rs2228570 FokI polymorphism) is associated with a decreased bone mineral density among white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by the two components, and it is influenced through chromosomal sites and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes carry an identifiable VDRE within their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) can be an archive of data and documents that are relevant to legal transactions, business or other procedures. Viewing, downloading or printing are not permitted. It uses a central server as well as an extranet connection which is an Internet connection with restricted access to allow controlled access to users at specific times at which users can access the data and documents.

VDRs are used most often by investment banks and businesses involved in mergers or acquisitions. They need to be able to communicate information in a clear manner with potential investors or buyers. Due diligence can also require a substantial amount of information. Life science companies also use VDRs to keep everything from clinical trials results to HIPAA documentation.

https://www.gescheftmarketing.de/2021/09/01/microsoft-teams-vs-zoom-which-one-is-better/


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